Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC chemokine receptor 1) and CXCR2, for which additional binding to endothelial HS-GAGs (heparan sulphate-glycosaminoglycans) is...

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Bibliographic Details
Main Authors: Mauro M. Teixeira, Andreas J. Kungl, Tiziana Adage, Angelika Falsone, Veronica Wabitsch, Elena Geretti, Heide Potzinger, Tanja Gerlza, James Robinson
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-09-01
Series:Bioscience Reports
Subjects:
anti-inflammatory
chemokine decoys
competition
GAG affinity
heparan sulphate
Online Access:http://www.bioscirep.org/bsr/033/e068/bsr033e068.htm

Internet

http://www.bioscirep.org/bsr/033/e068/bsr033e068.htm

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