Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Abstract Background Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported...

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Bibliographic Details
Main Authors: Maho Yokoyama, Emily Stevens, Maisem Laabei, Leann Bacon, Kate Heesom, Sion Bayliss, Nicola Ooi, Alex J. O’Neill, Ewan Murray, Paul Williams, Anneke Lubben, Shaun Reeksting, Guillaume Meric, Ben Pascoe, Samuel K. Sheppard, Mario Recker, Laurence D. Hurst, Ruth C. Massey
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Genome Biology
Subjects:
MRSA
Mupirocin resistance
Fitness costs
GWAS
Epistasis
Online Access:http://link.springer.com/article/10.1186/s13059-018-1469-2

Internet

http://link.springer.com/article/10.1186/s13059-018-1469-2

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