Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA
Abstract Background Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported...
Main Authors: | Maho Yokoyama, Emily Stevens, Maisem Laabei, Leann Bacon, Kate Heesom, Sion Bayliss, Nicola Ooi, Alex J. O’Neill, Ewan Murray, Paul Williams, Anneke Lubben, Shaun Reeksting, Guillaume Meric, Ben Pascoe, Samuel K. Sheppard, Mario Recker, Laurence D. Hurst, Ruth C. Massey |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-07-01
|
Series: | Genome Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13059-018-1469-2 |
Similar Items
-
Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)
by: Gustavo de los Campos, et al.
Published: (2019-05-01) -
Mutation and Epistasis in Influenza Virus Evolution
by: Daniel M. Lyons, et al.
Published: (2018-08-01) -
On the mechanistic nature of epistasis in a canonical cis-regulatory element
by: Mato Lagator, et al.
Published: (2017-05-01) -
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
by: Adami Christoph, et al.
Published: (2003-02-01) -
The Potential Power of Dynamics in Epistasis Analysis
by: Awdeh, Aseel
Published: (2015)