Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

<p>Abstract</p> <p>Background</p> <p>The MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour format...

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Bibliographic Details
Main Authors: Johnson Peter W, Robinson David O, Blaydes Jeremy P, White Helen E, Copson Ellen R, Eccles Diana M
Format: Article
Language:English
Published: BMC 2006-03-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/6/80