Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signalingResearch in context

Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signalingResearch in context

Background: Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it is unknown whether and ho...

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Bibliographic Details
Main Authors: Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li, Jingya Zhao, Xin Zhang, Lixing Zhan
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419305808

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http://www.sciencedirect.com/science/article/pii/S2352396419305808

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