Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebrafish xenografts. Our results show that this new sy...

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Bibliographic Details
Main Authors: Justyna Magdalena Hermanowicz, Anna Szymanowska, Beata Sieklucka, Robert Czarnomysy, Krystyna Pawlak, Anna Bielawska, Krzysztof Bielawski, Joanna Kalafut, Alicja Przybyszewska, Arkadiusz Surazynski, Adolfo Rivero-Muller, Mariusz Mojzych, Dariusz Pawlak
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
1,2,4-triazine derivative
apoptosis
colon cancer
zebrafish
Online Access:http://dx.doi.org/10.1080/14756366.2021.1879803

Internet

http://dx.doi.org/10.1080/14756366.2021.1879803

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