Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis

Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis

Abstract Acute pancreatitis (AP) remains a significant clinical challenge. Mitochondrial dysfunction contributes significantly to the pathogenesis of AP. Milk fat globule EGF factor 8 (MFG‐E8) is an opsonizing protein, which has many biological functions via binding to αvβ3/5 integrins. Ligand‐depen...

Full description

Bibliographic Details
Main Authors: Yifan Ren, Wuming Liu, Lin zhang, Jia Zhang, Jianbin Bi, Tao Wang, Mengzhou Wang, Zhaoqing Du, Yawen Wang, Zheng Wu, Yi Lv, Lingzhong Meng, Rongqian Wu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
acute pancreatitis
FAK‐STAT3
MFG‐E8
mitochondrial function
outcome
Online Access:https://doi.org/10.1002/ctm2.295

Internet

https://doi.org/10.1002/ctm2.295

Similar Items