Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease

Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease

Vision loss is among the characteristic symptoms of neuronal ceroid lipofuscinosis (NCL), a fatal neurodegenerative lysosomal storage disorder. Here, we performed an in-depth analysis of retinal degeneration at the molecular and cellular levels in mice lacking the lysosomal aspartyl protease catheps...

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Bibliographic Details
Main Authors: Mahmoud Bassal, Junling Liu, Wanda Jankowiak, Paul Saftig, Udo Bartsch
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
bipolar cells
ganglion cells
lysosomal storage disorder
neuronal ceroid lipofuscinosis
photoreceptor cells
retinal degeneration
Online Access:https://www.mdpi.com/2073-4409/10/3/696

Internet

https://www.mdpi.com/2073-4409/10/3/696

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