CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis

CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis

BackgroundMortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae, exceeds 50% in sub-Saharan African countries with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host and pathogen proteome in the CSF of adults with prov...

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Bibliographic Details
Main Authors: Emma C. Wall, Philip Brownridge, Gavin Laing, Vanessa S. Terra, Veronica Mlozowa, Brigitte Denis, Mulinda Nyirenda, Theresa Allain, Elisa Ramos-Sevillano, Enitan Carrol, Andrea Collins, Stephen B. Gordon, David G. Lalloo, Brendan Wren, Robert Beynon, Robert S. Heyderman, Jeremy S. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
meningitis
HIV—human immunodeficiency virus
mortality
Streptococcus pneumoniae
cerebrospinal fluid
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.603623/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2020.603623/full

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