Mutation and Epistasis in Influenza Virus Evolution
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus’s capacity to generate diversit...
Main Authors: | Daniel M. Lyons, Adam S. Lauring |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-08-01
|
Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/10/8/407 |
Similar Items
-
Stability-mediated epistasis constrains the evolution of an influenza protein
by: Lizhi Ian Gong, et al.
Published: (2013-05-01) -
Long-range Chained Epistasis in Influenza Viruses may not be Physically- but Functionally-mediated
by: Nshogozabahizi, Jean Claude
Published: (2015) -
Influenza evolution navigates stability valleys
by: Mary M Rorick, et al.
Published: (2013-05-01) -
Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
by: Angela M Phillips, et al.
Published: (2021-09-01) -
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
by: Adami Christoph, et al.
Published: (2003-02-01)