Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice

Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of Cd39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39+/+/ApoE−/−) and Cd39/ApoE double KO (DKO) (C...

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Bibliographic Details
Main Authors: Marco De Giorgi, Keiichi Enjyoji, Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Richard J. Gumina, Ryszard T. Smolenski, Simon C. Robson
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cholesterol/efflux
macrophages
vascular biology
foam cells
cluster of differentiation 39
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335811

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http://www.sciencedirect.com/science/article/pii/S0022227520335811

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