A novel role for 12/15-lipoxygenase in regulating autophagy

A novel role for 12/15-lipoxygenase in regulating autophagy

12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material, indicating defects in autophagy or membrane pr...

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Bibliographic Details
Main Authors: Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Lipid
Autophagy
Lipoxygenase
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001177

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http://www.sciencedirect.com/science/article/pii/S2213231714001177

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