(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (<i>Lim</i>-SLNs), stabilized with Poloxamer<sup>&#174;</sup> 188 in aqueous dispersion to modify the release profile of the loaded monoterpene...

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Bibliographic Details
Main Authors: Eliana B. Souto, Aleksandra Zielinska, Selma B. Souto, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Amélia M. Silva, Atanas G. Atanasov, Conrado Marques, Luciana N. Andrade, Patricia Severino
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
(+)-limonene 1,2-epoxide
monoterpene
imwitor 900k-sln
lipid peroxidation
cytotoxicity
hacat cell line
Online Access:https://www.mdpi.com/1422-0067/21/4/1449

Internet

https://www.mdpi.com/1422-0067/21/4/1449

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