Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload.

Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload.

Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely unexplored. A rat model of pressure-loaded heart is developed by trans-aortic constriction (TAC)...

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Bibliographic Details
Main Authors: Lei Ye, Liping Su, Chenxu Wang, Szejie Loo, Guizhen Tee, Shihua Tan, Sandar Win Khin, Shijie Ko, Boyang Su, Stuart A Cook
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6067738?pdf=render

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http://europepmc.org/articles/PMC6067738?pdf=render

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