Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA

Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA

Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully characterized, and their interaction with DNA was also...

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Bibliographic Details
Main Authors: Láuris Lucia da Silva, Claudio Luis Donnici, Júlio César Dias Lopes, Marília Oliveira Fonseca Goulart, Fabiane Caxico de Abreu, Francine Santos de Paula, Carlos E. Salas Bravo, Marcelo Matos Santoro, Ângelo Márcio Leite Denadai, Alexandre Martins Costa Santos, Carlos Alberto Montanari
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
biscationic compounds and interaction with DNA
isothermal titration calorimetry
electrochemical biosensor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700007&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700007&lng=en&tlng=en

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