Integration of principles of systems biology and radiation biology: toward development of in silico models to optimize IUdR-mediated radiosensitization of DNA mismatch repair-deficient (damage tolerant) human cancers

Integration of principles of systems biology and radiation biology: toward development of in silico models to optimize IUdR-mediated radiosensitization of DNA mismatch repair-deficient (damage tolerant) human cancers

Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base damage by DNA mismatch repair (MMR). These coordin...

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Bibliographic Details
Main Authors: Timothy James Kinsella, Evren eGurkan-Cavusoglu, Weinan eDu, Kenneth eLoparo
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Oncology
Subjects:
Systems Biology
mismatch repair
iododeoxyuridine
Ionizing radiation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00020/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00020/full

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