TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

Summary: We screen ion channels and transporters throughout the genome to identify those required by human melanoma cells but not by normal human melanocytes. We discover that Mucolipin-1 (MCOLN1), which encodes the lysosomal cation channel TRPML1, is preferentially required for the survival and pro...

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Bibliographic Details
Main Authors: Stacy Y. Kasitinon, Ugur Eskiocak, Misty Martin, Divya Bezwada, Vishal Khivansara, Alpaslan Tasdogan, Zhiyu Zhao, Thomas Mathews, Arin B. Aurora, Sean J. Morrison
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310022

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http://www.sciencedirect.com/science/article/pii/S2211124719310022

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