Application of the Moran Model in Estimating Selection Coefficient of Mutated CSF3R Clones in the Evolution of Severe Congenital Neutropenia to Myeloid Neoplasia

Application of the Moran Model in Estimating Selection Coefficient of Mutated CSF3R Clones in the Evolution of Severe Congenital Neutropenia to Myeloid Neoplasia

Bone marrow failure (BMF) syndromes, such as severe congenital neutropenia (SCN) are leukemia predisposition syndromes. We focus here on the transition from SCN to pre-leukemic myelodysplastic syndrome (MDS). Stochastic mathematical models have been conceived that attempt to explain the transition o...

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Bibliographic Details
Main Authors: Khanh N. Dinh, Seth J. Corey, Marek Kimmel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
clinical data
G-CSF receptor (G-CSFR)
recurrent mutation
myeloid neoplasia
Moran model
selective advantage
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00806/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00806/full

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