Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts

Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts

Sepsis/endotoxemia activates the NLRP3 inflammasome of macrophages leading to the maturation and release of IL-1β, an important mediator of the inflammatory response. Reactive oxygen species have been implicated in NLRP3 inflammasome activation. Further, our preliminary studies indicated that LPS ch...

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Bibliographic Details
Main Authors: Ting Lan, Aibin Tao, Xuemei Xu, Peter Kvietys, Tao Rui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
NLRP3 inflammasome
cardiac fibroblast
protein kinase R
peroxynitrite
IL-1β
caspase 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.558712/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.558712/full

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