A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

Postoperative ileus (POI) is triggered by an innate immune response in the muscularis externa (ME) and is accompanied by bacterial translocation. Bacteria can trigger an innate immune response via toll-like receptor (TLR) activation, but the latter’s contribution to POI has been disproved for severa...

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Bibliographic Details
Main Authors: Jana Enderes, Shilpashree Mallesh, Reiner Schneider, Kristof J. Hupa, Mariola Lysson, Bianca Schneiker, Kristian Händler, Balthasar Schlotmann, Patrick Günther, Joachim L. Schultze, Jörg C. Kalff, Sven Wehner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
postoperative ileus
TLR3
TRIF
macrophages
innate immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.581111/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.581111/full

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