Discovery of a CLN7 model of Batten disease in non-human primates

Discovery of a CLN7 model of Batten disease in non-human primates

We have identified a natural Japanese macaque model of the childhood neurodegenerative disorder neuronal ceroid lipofuscinosis, commonly known as Batten Disease, caused by a homozygous frameshift mutation in the CLN7 gene (CLN7−/−). Affected macaques display progressive neurological deficits includi...

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Bibliographic Details
Main Authors: Jodi L. McBride, Martha Neuringer, Betsy Ferguson, Steven G. Kohama, Ian J. Tagge, Robert C. Zweig, Laurie M. Renner, Trevor J. McGill, Jonathan Stoddard, Samuel Peterson, Weiping Su, Larry S. Sherman, Jacqueline S. Domire, Rebecca M. Ducore, Lois M. Colgin, Anne D. Lewis
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Neurobiology of Disease
Subjects:
CLN7
MFSD8
Late infantile neuronal ceroid lipofuscinosis
Batten disease
Non-human primate
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118302560

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http://www.sciencedirect.com/science/article/pii/S0969996118302560

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