Capillarized Liver Sinusoidal Endothelial Cells Undergo Partial Endothelial-Mesenchymal Transition to Actively Deposit Sinusoidal ECM in Liver Fibrosis

Capillarized Liver Sinusoidal Endothelial Cells Undergo Partial Endothelial-Mesenchymal Transition to Actively Deposit Sinusoidal ECM in Liver Fibrosis

Tissue-specific endothelial cells are more than simply a barrier lining capillaries and are proved to be capable of remarkable plasticity to become active collagen matrix-producing myofibroblasts (MFs) in solid organs with fibrosis. Liver sinusoidal endothelial cells (LSECs) also participate in the...

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Bibliographic Details
Main Authors: Bai Ruan, Juan-Li Duan, Hao Xu, Kai-Shan Tao, Hua Han, Guo-Rui Dou, Lin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
liver fibrosis
extracellular matrix
myofibroblasts
endothelial cells
capillarization
endothelial-mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.671081/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.671081/full

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