Validation of Liquid Chromatography-Tandem Mass Spectrometry-Based 5-Plex Assay for Mucopolysaccharidoses

Validation of Liquid Chromatography-Tandem Mass Spectrometry-Based 5-Plex Assay for Mucopolysaccharidoses

Mucopolysaccharidoses (MPSs) are rare lysosomal storage diseases caused by the accumulation of undegraded glycosaminoglycans in cells and tissues. The effectiveness of early intervention for MPS has been reported. Multiple-assay formats using tandem mass spectrometry have been developed. Here, we de...

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Bibliographic Details
Main Authors: Tsubasa Oguni, Shunji Tomatsu, Misa Tanaka, Kenji Orii, Toshiyuki Fukao, Jun Watanabe, Seiji Fukuda, Yoshitomo Notsu, Dung Chi Vu, Thi Bich Ngoc Can, Atsushi Nagai, Seiji Yamaguchi, Takeshi Taketani, Michael H. Gelb, Hironori Kobayashi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
mucopolysaccharidosis
newborn screening
enzyme assay
liquid chromatography tandem mass spectrometry
Online Access:https://www.mdpi.com/1422-0067/21/6/2025

Internet

https://www.mdpi.com/1422-0067/21/6/2025

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