A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant <i>Escherichia coli</i>

A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant <i>Escherichia coli</i>

Resistance to polymyxins when treating multidrug-resistant (MDR) Gram-negative bacterial infections limit therapeutic options. Here, we report the synthesis of a nickel (Ni) doped Zinc oxide (NZO) combined with black phosphorus (BP) (NZB) nanocomposite and its synergistic action with polymyxin B (Po...

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Bibliographic Details
Main Authors: Hyejin Cho, Atanu Naskar, Sohee Lee, Semi Kim, Kwang-Sun Kim
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
nano-antibiotics
black phosphorus
polymyxin-resistant Gram-negative bacteria
charge neutralization mechanism
Mcr-1
Online Access:https://www.mdpi.com/1999-4923/13/2/250

Internet

https://www.mdpi.com/1999-4923/13/2/250

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