Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy

Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy

The ubiquitin–proteasome system has the capacity to degrade polyubiquitinated proteins and plays an important role in many cellular processes. However, the role of Rpt3, a crucial proteasomal gene, has not been investigated in adult muscles in vivo. Herein, we generated skeletal-muscle-specific Rpt3...

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Bibliographic Details
Main Authors: Yasuo Kitajima, Naoki Suzuki, Kiyoshi Yoshioka, Rumiko Izumi, Maki Tateyama, Yoshitaka Tashiro, Ryosuke Takahashi, Masashi Aoki, Yusuke Ono
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
muscle homeostasis
Rpt3
ubiquitin proteasome system
muscle atrophy
adult skeletal muscle
sarcopenia
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00859/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00859/full

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