Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy

Voltage-dependent Na+currents were recorded via patch-clamp from identified adult rat lumbar cutaneous dorsal root ganglion (DRG) neurones using whole-cell and bleb-patch-clamp configurations. Na+currents in DRG neurones studied 18 days after sciatic nerve ligation were compared with those in contro...

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Bibliographic Details
Main Authors: Marco A. Rizzo, Jeffrey D. Kocsis, Stephen G. Waxman
Format: Article
Language:English
Published: Elsevier 1995-04-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996185700095