V363I and V363A mutated tau affect aggregation and neuronal dysfunction differently in C. elegans

V363I and V363A mutated tau affect aggregation and neuronal dysfunction differently in C. elegans

Mutations in the microtubule-associated protein tau (MAPT) gene have been linked to a heterogeneous group of progressive neurodegenerative disorders commonly called tauopathies. From patients with frontotemporal lobar degeneration with distinct atypical clinical phenotypes, we recently identified tw...

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Bibliographic Details
Main Authors: Federica Morelli, Margherita Romeo, Maria Monica Barzago, Marco Bolis, Davide Mattioni, Giacomina Rossi, Fabrizio Tagliavini, Antonio Bastone, Mario Salmona, Luisa Diomede
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neurobiology of Disease
Subjects:
Frontotemporal dementia
Tauopathies
Microtubule-associated protein tau
Tau
Proteotoxicity
Oligomers
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301967

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http://www.sciencedirect.com/science/article/pii/S0969996118301967

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