Phosphoramidates and phosphonamidates (ProTides) with antiviral activity

Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in 1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in many laboratories. Designed with aim to overcome limitations and the key resistance mechanisms associated with nucleoside...

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Bibliographic Details
Main Authors: Magdalena Slusarczyk, Michaela Serpi, Fabrizio Pertusati
Format: Article
Language:English
Published: SAGE Publishing 2018-05-01
Series:Antiviral Chemistry & Chemotherapy
Online Access:https://doi.org/10.1177/2040206618775243