PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

PCDH19-Girls Clustering Epilepsy (PCDH19-GCE) is a childhood epileptic encephalopathy characterised by a spectrum of neurodevelopmental problems. PCDH19-GCE is caused by heterozygous loss-of-function mutations in the X-chromosome gene, Protocadherin 19 (PCDH19) encoding a cell-cell adhesion molecule...

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Bibliographic Details
Main Authors: Claire C. Homan, Stephen Pederson, Thu-Hien To, Chuan Tan, Sandra Piltz, Mark A. Corbett, Ernst Wolvetang, Paul Q. Thomas, Lachlan A. Jolly, Jozef Gecz
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Neurobiology of Disease
Subjects:
PCDH19
Epilepsy
Neurogenesis
Induced pluripotent stem cells
Polarity
Neural stem and progenitor cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301426

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http://www.sciencedirect.com/science/article/pii/S0969996118301426

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