Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Abstract Pathogenesis in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorders (herein called NMO) involves complement-dependent cytotoxicity initiated by AQP4-IgG binding to astrocyte AQP4. We recently reported that rats lacking complement inhibitor protein CD...

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Bibliographic Details
Main Authors: Xiaoming Yao, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Acta Neuropathologica Communications
Subjects:
NMO
Aquaporin-4
Complement inhibitor
Skeletal muscle
Kidney
Astrocyte
Online Access:http://link.springer.com/article/10.1186/s40478-017-0462-4

Internet

http://link.springer.com/article/10.1186/s40478-017-0462-4

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