Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins

Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins

Isocitrate dehydrogenases (IDH) 1 and 2 are key metabolic enzymes that generate reduced nicotinamide adenine dinucleotide phosphate (NADPH) to maintain a pool of reduced glutathione and peroxiredoxin, and produce α-ketoglutarate, a co-factor of numerous enzymes. IDH1/2 is mutated in ~70&am...

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Bibliographic Details
Main Authors: Bozena Kaminska, Bartosz Czapski, Rafal Guzik, Sylwia Katarzyna Król, Bartlomiej Gielniewski
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
IDH mutations
metabolic disturbances
epigenetics
gliomas
tumor microenvironment
IHD mutant inhibitors
Online Access:http://www.mdpi.com/1420-3049/24/5/968

Internet

http://www.mdpi.com/1420-3049/24/5/968

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