Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

Abstract Background Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied. Many studies have revealed marked alterations of standard prognostic...

Full description

Bibliographic Details
Main Authors: Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Breast cancer
Metastasis
Exome sequencing
Somatic mutations
AKAP
A-kinase anchoring proteins
Online Access:http://link.springer.com/article/10.1186/s12885-018-4021-6

Internet

http://link.springer.com/article/10.1186/s12885-018-4021-6

Similar Items