HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis

HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis

We previously reported that PP242 (dual inhibitor of mTORC1/2) plus curcumin induced apoptotic cell death through lysosomal membrane permeabilization (LMP)-mediated autophagy. However, the relationship between ER stress and apoptotic cell death by combined PP242 and curcumin treatment remains unknow...

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Bibliographic Details
Main Authors: Seung Un Seo, Kyoung-jin Min, Seon Min Woo, Ji Hae Seo, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
mTORC1/2
curcumin
PP242
ER stress
HSP70
acetylation
Online Access:https://www.mdpi.com/1420-3049/23/11/2755

Internet

https://www.mdpi.com/1420-3049/23/11/2755

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