Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.

Oxidative stress and inflammation are two critical factors that drive the formation of plaques in atherosclerosis. Nrf2 is a redox-sensitive transcription factor that upregulates a battery of antioxidative genes and cytoprotective enzymes that constitute the cellular response to oxidative stress. Ou...

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Bibliographic Details
Main Authors: Thomas E Sussan, Jonathan Jun, Rajesh Thimmulappa, Djahida Bedja, Maria Antero, Kathleen L Gabrielson, Vsevolod Y Polotsky, Shyam Biswal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2582492?pdf=render