4-AP-3-MeOH Promotes Structural and Functional Spontaneous Recovery in the Acute Sciatic Nerve Stretch Injury

Background: 4-AP-3-MeOH, a derivative of 4-aminopyridine, was developed and demonstrated to prevent nerve pulse diffusion due to myelin damage and significantly enhance axonal conduction following nerve injury. Currently, repurposing the existing drug such as 4-AP-3-MeOH to restore motor function is...

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Bibliographic Details
Main Authors: Yan Chen, Weidong Wang, Zhimin Zhao, Dong Ren, Danmou Xin
Format: Article
Language:English
Published: SAGE Publishing 2020-01-01
Series:Dose-Response
Online Access:https://doi.org/10.1177/1559325819899254