PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal en...

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Bibliographic Details
Main Authors: Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Sihem Boudina, Michael Courtois, David F Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O Holloszy, Denis M Medeiros, Robert E Schmidt, Jeffrey E Saffitz, E Dale Abel, Clay F Semenkovich, Daniel P Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1064854?pdf=render

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http://europepmc.org/articles/PMC1064854?pdf=render

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