Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies

Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies

Abstract Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic centres, basal ganglia and cerebellar circuits. It has been suggested that primary...

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Bibliographic Details
Main Authors: Violetta Refolo, Francesco Bez, Alexia Polissidis, Daniela Kuzdas-Wood, Edith Sturm, Martina Kamaratou, Werner Poewe, Leonidas Stefanis, M. Angela Cenci, Marina Romero-Ramos, Gregor K. Wenning, Nadia Stefanova
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple system atrophy
Striatonigral degeneration
α-synuclein, transgenic mouse
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s40478-017-0504-y

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http://link.springer.com/article/10.1186/s40478-017-0504-y

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