Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer

As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis. The identification of proteins that undergo calpain cleavage in a site-specific...

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Bibliographic Details
Main Authors: Ze-Xian Liu, Kai Yu, Jingsi Dong, Linhong Zhao, Zekun Liu, Qingfeng Zhang, Shihua Li, Yimeng Du, Han Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00715/full