Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo

Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo

Squamous Cell Carcinoma-derived Stem-like Cells (SCC-SC) originate from alterations in keratinocyte stem cells (KSC) gene expression and sustain tumor development, invasion and recurrence. Since survivin, a KSC marker, is highly expressed in SCC-SC, we evaluate its role in SCC-SC cell growth and SCC...

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Bibliographic Details
Main Authors: Roberta Lotti, Elisabetta Palazzo, Tiziana Petrachi, Katiuscia Dallaglio, Annalisa Saltari, Francesca Truzzi, Marika Quadri, Mario Puviani, Antonino Maiorana, Alessandra Marconi, Carlo Pincelli
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
squamous cell carcinoma
stem cells
β1-integrin
tumor formation
survivin
rapidly adhering cells
skin
tumorigenesis
differentiation
Online Access:http://www.mdpi.com/1422-0067/17/1/89

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http://www.mdpi.com/1422-0067/17/1/89

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