Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication

Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication

In fission yeast, the small, intrinsically disordered protein S-phase delaying protein 1 (Spd1) blocks DNA replication and causes checkpoint activation at least in part, by inhibiting the enzyme ribonucleotide reductase, which is responsible for the synthesis of DNA. The CRL4Cdt2 E3 ubiquitin ligase...

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Bibliographic Details
Main Authors: Oliver Fleck, Ulrik Fahnøe, Katrine Vyff Løvschal, Marie-Fabrice Uwamahoro Gasasira, Irina N. Marinova, Birthe B. Kragelund, Antony M. Carr, Edgar Hartsuiker, Christian Holmberg, Olaf Nielsen
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Genes
Subjects:
DNA replication
checkpoints
ribonucleotide reductase
PCNA
CRL4Cdt2
intrinsically disordered proteins
deoxynucleotide salvage
fission yeast
Online Access:http://www.mdpi.com/2073-4425/8/5/128

Internet

http://www.mdpi.com/2073-4425/8/5/128

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