Chronic kidney disease and fibrosis: the role of uremic retention solutes

Chronic kidney disease and fibrosis: the role of uremic retention solutes

Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues. Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. Ano...

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Bibliographic Details
Main Authors: Henricus A.M. Mutsaers, Elisabeth G.D. Stribos, Griet eGlorieux, Raymond eVanholder, Peter eOlinga
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Medicine
Subjects:
Chronic Kidney Disease
epithelial-to-mesenchymal transition
renal fibrosis
cardiac fibrosis
TGF- β
uremic retention solutes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00060/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00060/full

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