Chronic kidney disease and fibrosis: the role of uremic retention solutes
Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues. Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. Ano...
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doaj-16c8d0329963413397012d94075d32bd2020-11-24T22:59:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2015-08-01210.3389/fmed.2015.00060152613Chronic kidney disease and fibrosis: the role of uremic retention solutesHenricus A.M. Mutsaers0Elisabeth G.D. Stribos1Griet eGlorieux2Raymond eVanholder3Peter eOlinga4University of GroningenUniversity of GroningenGhent University HospitalGhent University HospitalUniversity of GroningenChronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues. Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. Another key feature of CKD is the retention and subsequent accumulation of solutes that are normally cleared by the healthy kidney. Several of these uremic retention solutes, including indoxyl sulfate and p-cresyl sulfate, have been suggested to be CKD-specific triggers for the development and perpetuation of fibrosis. The purpose of this brief review is to gather and discuss the current body of evidence linking uremic retention solutes to the fibrotic response during CKD, with a special emphasis on the pathophysiological mechanisms in the kidney.http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00060/fullChronic Kidney Diseaseepithelial-to-mesenchymal transitionrenal fibrosiscardiac fibrosisTGF- βuremic retention solutes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Henricus A.M. Mutsaers Elisabeth G.D. Stribos Griet eGlorieux Raymond eVanholder Peter eOlinga |
spellingShingle |
Henricus A.M. Mutsaers Elisabeth G.D. Stribos Griet eGlorieux Raymond eVanholder Peter eOlinga Chronic kidney disease and fibrosis: the role of uremic retention solutes Frontiers in Medicine Chronic Kidney Disease epithelial-to-mesenchymal transition renal fibrosis cardiac fibrosis TGF- β uremic retention solutes |
author_facet |
Henricus A.M. Mutsaers Elisabeth G.D. Stribos Griet eGlorieux Raymond eVanholder Peter eOlinga |
author_sort |
Henricus A.M. Mutsaers |
title |
Chronic kidney disease and fibrosis: the role of uremic retention solutes |
title_short |
Chronic kidney disease and fibrosis: the role of uremic retention solutes |
title_full |
Chronic kidney disease and fibrosis: the role of uremic retention solutes |
title_fullStr |
Chronic kidney disease and fibrosis: the role of uremic retention solutes |
title_full_unstemmed |
Chronic kidney disease and fibrosis: the role of uremic retention solutes |
title_sort |
chronic kidney disease and fibrosis: the role of uremic retention solutes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2015-08-01 |
description |
Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues. Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. Another key feature of CKD is the retention and subsequent accumulation of solutes that are normally cleared by the healthy kidney. Several of these uremic retention solutes, including indoxyl sulfate and p-cresyl sulfate, have been suggested to be CKD-specific triggers for the development and perpetuation of fibrosis. The purpose of this brief review is to gather and discuss the current body of evidence linking uremic retention solutes to the fibrotic response during CKD, with a special emphasis on the pathophysiological mechanisms in the kidney. |
topic |
Chronic Kidney Disease epithelial-to-mesenchymal transition renal fibrosis cardiac fibrosis TGF- β uremic retention solutes |
url |
http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00060/full |
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