Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

Neuronal lactate uptake supports energy metabolism associated with synaptic signaling and recovery of extracellular ion gradients following neuronal activation. Altered expression of the monocarboxylate transporters (MCT) in temporal lobe epilepsy (TLE) hampers lactate removal into the bloodstream....

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Bibliographic Details
Main Authors: Eskedar Ayele Angamo, Rizwan ul Haq, Jörg Rösner, Siegrun Gabriel, Zoltán Gerevich, Uwe Heinemann, Richard Kovács
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
lactate
monocarboxylate transporter inhibitors
seizure
interictal activity
mesial temporal lobe epilepsy
adenosine
Online Access:https://www.mdpi.com/1422-0067/18/9/1835

Internet

https://www.mdpi.com/1422-0067/18/9/1835

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