Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia

Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia

Abstract Delayed emergence from anesthesia was previously reported in a case study of a child with Glycine Encephalopathy. To investigate the neural basis of this delayed emergence, we developed a zebrafish glial glycine transporter (glyt1 − / −) mutant model. We compared locomotor behaviors; dose–r...

Full description

Bibliographic Details
Main Authors: Michael J. Venincasa, Owen Randlett, Sureni H. Sumathipala, Richard Bindernagel, Matthew J. Stark, Qing Yan, Steven A. Sloan, Elena Buglo, Qing Cheng Meng, Florian Engert, Stephan Züchner, Max B. Kelz, Sheyum Syed, Julia E. Dallman
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82342-w

Internet

https://doi.org/10.1038/s41598-021-82342-w

Similar Items