Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a variant (rs344) in the HBB gene encoding the β-globin subunit of hemoglobin. Chronic hemolytic anemia and increased erythropoiesis and RBC turnover in individuals with SCD can result in increased needs for folate and other B-vita...

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Bibliographic Details
Main Authors: Brock A. Williams, Cara Mayer, Heather McCartney, Angela M. Devlin, Yvonne Lamers, Suzanne M. Vercauteren, John K. Wu, Crystal D. Karakochuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Nutrition
Subjects:
sickle cell disease
pediatrics
folate
unmetabolized folic acid
B-vitamins
nutrition
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.642306/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.642306/full

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