Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation

Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation

Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and modulating their activities. We investigated the role of RNA1.2,...

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Bibliographic Details
Main Authors: Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolás M. Suárez, Richard J. Stanton, Eddie C. Y. Wang, Michael P. Weekes, Andrew J. Davison
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
human cytomegalovirus
lncRNA
IL-6
gene regulation
transcriptomics
TPRG1L
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00361/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00361/full

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