Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

Iron oxide-based nanoparticles have been repeatedly shown to affect lysosomal-mediated signaling. Recently, nanoparticles have demonstrated an ability to modulate autophagic flux via lysosome-dependent signaling. However, the precise underlying mechanisms of such modulation as well as the impact of...

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Bibliographic Details
Main Authors: Mariia Uzhytchak, Barbora Smolková, Mariia Lunova, Milan Jirsa, Adam Frtús, Šárka Kubinová, Alexandr Dejneka, Oleg Lunov
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
nano-bio interactions
iron oxide nanoparticles
autophagy
lysosomes
magnetic resonance imaging
p53
Online Access:https://www.mdpi.com/2073-4409/9/4/1015

Internet

https://www.mdpi.com/2073-4409/9/4/1015

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