Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
<p>SIRT1, a homolog of yeast Sir2, is a type III NAD<sup>+</sup> dependent histone and protein deacetylase. Previous studies of mice carrying liver specific deletion of exon 4 of the <i>Sirt1 </i>gene revealed opposite responses of mutant mice to a high-fat diet in term...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2010-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v06p0682.htm |