Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives

Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives

The crude extract of Streptomyces chrestomyceticus exhibited strong and broad activities against most “ESKAPE pathogens.” We conducted a comprehensive chemical investigation for secondary metabolites from the S. chrestomyceticus strain and identified two novel albofungin (alb) derivatives, i.e., alb...

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Bibliographic Details
Main Authors: Weiyi She, Wenkang Ye, Aifang Cheng, Xin Liu, Jianwei Tang, Yi Lan, Feng Chen, Pei-Yuan Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
polycyclic xanthones
actinobacteria
heterologous expression
antibiotics
antitumor
albofungin biosynthetic gene cluster
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.635268/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.635268/full

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