Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

OBJECTIVE:The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to chemotherapy. DESIGN:This retrospective obser...

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Main Authors: Oscar Murcia, Míriam Juárez, María Rodríguez-Soler, Eva Hernández-Illán, Mar Giner-Calabuig, Miren Alustiza, Cecilia Egoavil, Adela Castillejo, Cristina Alenda, Víctor Barberá, Carolina Mangas-Sanjuan, Ana Yuste, Luís Bujanda, Joan Clofent, Montserrat Andreu, Antoni Castells, Xavier Llor, Pedro Zapater, Rodrigo Jover
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6126803?pdf=render

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http://europepmc.org/articles/PMC6126803?pdf=render

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